Keisham Surjit Singh
National Institute of Technology Agartala, India
Title: Synthesis, structural characterization and anti-diabetic activities of organotin(IV) azo-carboxylates: Crystal structure of a 48 membered macrocyclic-tetrameric trimethyltin(IV) complex
Biography
Biography: Keisham Surjit Singh
Abstract
Triorganotin(IV) complexes of azo-carboxylic acids were synthesized by the reaction of 2/4-(2,4-dihydroxy-phenylazo)-benzoic acids with appropriate triorganotin(IV) chlorides [R= Me (1 and 3), Ph (2 and 4) and Bu (5)] in presence of triethylamine. The characterization of the complexes was accomplished by elemental analyses, UV, IR and multinuclear (1H, 13C and 119Sn) NMR spectroscopy. Structure of compound 3 was established by X-ray crystal structure analysis. X-ray crystal structure of 3 revealed that the compound exhibits a 48 membered macrocyclic-tetrameric structure with trigonal bipyramidal geometry around the tin atoms in which the three methyl groups occupy the equatorial positions while the apical positions are being occupied by the oxygen atom of carboxylate group of one ligand and the phenoxide oxygen atom of another ligand. All the complexes display a sharp singlet 119Sn resonance in the range specified for the four coordinate structures suggesting that complexes have tetrahedral structures in solution. The five coordinate structure of the complexes in solid state dissociated into monomeric species with four coordinate structures in solution. Anti-diabetic activities of the complexes were studied and the results showed that the synthesized compounds exhibited effective activity even higher than the standard compound acarbose.