Mustafa Arslan
Sakarya University, Turkey
Title: Synthesis of sulfonamide compounds bearing thiazole ring
Biography
Biography: Mustafa Arslan
Abstract
Heterocyclic moieties, such as indoles, thiazolidine-4-ones, pyrazoles, piperazines, pyridines, etc., always have considerable attention due to their pharmacological activities. Heterocycles bearing one or more nitrogen and sulfur atoms have received more attention recently. Among the most frequently encountered heterocyclic compounds, thiazole and its derivatives play an important role in nature. The heterocyclic compounds have broad applications including the treatment of hypertension, bacterial and HIV infections, allergies and as antibiotics and ligands for estrogen receptors. Besides, these compounds have used as inhibitors against fructose 1, 6-bisphosphatase, tumor associated carbonic anhydrase isoforms hCA IX and hCA XII, sphingosine kinase and evaluation of in vitro anticancer activity. 12 sulfonamide bearing thiazole compounds were synthesized for the investigation of carbonic anhydrase enzyme activity.