Mustafa Kucukislamoglu
Sakarya University, Turkey
Title: Synthesis of New Coumaryl-3-Carboxamide Derivatives
Biography
Biography: Mustafa Kucukislamoglu
Abstract
The synthesis, reactions and biological properties of substituted coumarins constitute a significant part of modern heterocyclic chemistry. Compounds containing a coumarin moiety display a broad spectrum of biological activities such as antimicrobial, antifungal, anticoagulant, anti-HIV and insecticidal properties. Coumarins are an important class of CAIs for several reasons: (i) they were the first CAIs showing a high selectivity for inhibiting CA isoforms of interest for pharmacologic applications, such as the tumor-associated ones (hCA IX and XII, which are targets for antitumor/ anti-metastatic drugs) or the mitochondrial ones (CA VA and VB, which are targets for anti-obesity agents). 20 thiourea bearing coumaryl-3-carboxamid compounds were synthesized for the investigation of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities.