John Nafea Phillopes
Beni-Suef University, Egypt
Title: Design and synthesis of novel benzimidazole, benzoxazole and benzothiazole derivatives bearing biologically active thiazole, dihydroquinolone and thiazolidinone moieties as a new class of antitumor agents
Biography
Biography: John Nafea Phillopes
Abstract
Three new series of thiazoles, quinolones and thiazolidinones merged with benzimidazole, benzoxazole and benzothiazole nuclei were synthesized. All the prepared compounds were subjected to IR, 1H NMR, 13C NMR, mass spectral data and elemental analyses. Cytotoxic activity of the synthesized compounds were evaluated against two different types of cancer cells, breast (MCF-7) and colon cancer (HCT-116) cell lines. Seven compounds showed potent cytotoxic activity compared with doxorubicin, the reference drug with IC50 between 0.0125-0.0198 µM.