Mustafa Zengin
Sakarya University, Turkey
Title: Antibacterial activity of thiazolidine-4-carboxylic acid derivatives
Biography
Biography: Mustafa Zengin
Abstract
Nitrogen-containing five-membered heterocyclic compounds are found in the structures of several natural products and pharmaceuticals. Most of them are used as synthetic intermediate products, reactants, ligands, or asymmetric synthesis catalysts1. Because their many synthesized derivatives are biologically active, thiazolidine has recently become an increasingly used heterocyclic system2,3. We synthesized TCA derivatives and investigated their antibacterial properties on multi-drug resistant (MDR) bacteria. The result showed that TCAs have significant antibacterial activity on Gram-positive (S. aureus) and Gram-negative bacteria (Pseudomanas, Acinetobacter, and Escherichia coli). TCA derivatives are structural analogue of proline. Therefore, it can inhibit bacterial growth by mimicking various essential functions of naturally occurring amino acids4. The molecules have been synthesized for antibacterial studies at a high yield using cheap and easily accessible starting materials.